IGF-1 Receptor and Longevity

IGF-1 (Insulin-Like Growth Factor-1) belongs to the insulin family of peptides and acts as a growth factor in many tissues and tumors. Locally acting isoform of IGF-1 targeted to skeletal muscle enhances muscle growth and differentiation, prevents age-related muscle atrophy, and potentiates regeneration after injury. Similarly, cardiac restricted expression of IGF-1 increases the formation of ventricular myocytes, attenuates myocyte death, and delays the development of an aging myopathy. In the heart, the IGF-1–IGF-1 receptor system induces division of cardiac stem cells (CSCs), upregulates telomerase activity, hinders replicative senescence, and preserves the pool of functionally competent CSCs. It has been demonstrated that an IGF-1 receptor pathway reproduces many of the effects of caloric restriction to increase the lifespan of test animals, and possibly humans too.

Click gene symbol on the map to view ORF/cDNA clone.

Data source: KEGG, BioCarta