IFN gamma signaling pathway

Interferon (IFN) gamma is secreted from CD4+ Th1 cells, CD8 cells, gamma/delta T cells and activated NK cells. It plays a role in activating lymphocytes to enhance anti-microbial and anti-tumor effects. In addition it plays a role in regulating the proliferation, differentiation, and response of lymphocyte subsets. Signaling takes place through a IFN Recpetor complex consisting of two alpha chains (Type I receptor) and two beta chains (Type 2 receptor). Upon phosphorylation by Jak1, Stat1(alpha) transduces the signal into transcriptional events.