IFN alpha signaling pathway

Interferons (IFNs) are pleiotropic cytokines that exhibit important biologic activities, including antiviral, antiproliferative, antitumor and immunomodulatory effects. IFNs are classified as either Type I or Type II. Type I IFNs include the IFN-alpha family of 13 subtypes, IFN-beta, IFN-omega, IFN-tau, IFN-kappa, IFN-lambda, and IFN-zeta. By contrast, there is only one Type-II IFN, IFN-gamma. IFN-alpha and IFN-beta bind to the type I IFN receptor (IFN-alpha/beta receptor) consisting of two subunits, Interferon (alpha, beta and omega) receptor 1 ( IFNAR1) and Interferon (alpha, beta and omega) receptor 2 (IFNAR2). Interferon alpha plays a role in viral infections. Signaling takes place through an IFN Receptor complex consisting of two alpha chains (Type I receptor) in complex with Jak1 and Tyk2. These kinases phosphorylate Stat1 and Stat2 respectively.

Click gene symbol on the map to view ORF/cDNA clone.

Data source: KEGG, BioCarta