Protein Kinase C Signaling Pathway

Protein Kinase C (PKC) is a family of enzymes that phosphorylate the hydroxyl groups of serine and threonine amino acid residues of their target proteins. PKCs themselves are activated by signals such as increases in the concentration of diacylglycerol or Ca2+. Hence, PKC enzymes play important roles in several signal transduction cascades.

There are 10 PKC isozymes. They are divided into three subfamilies according to their second messenger requirements: conventional (or classical), novel, and atypical.

Click gene symbol on the map to view ORF/cDNA clone.

Data source: KEGG, BioCarta