TPO Signaling Pathway

(Thrombopoietin) TPO and its receptor c-Mpl are the primary regulators of megakaryocytopoiesis and are important for hematopoietic stem cells.

The binding of TPO to c-Mpl promotes the phosphorylation of cytoplasmic signaling proteins and activation of a number of cascades that control cellular proliferation, megakaryocyte development, and survival. Suppressors of cytokine signaling (SOCS), phosphatases, and other proteins, such as focal adhesion kinase and members of the Src family kinases can suppress TPO signaling.

Click gene symbol on the map to view ORF/cDNA clone.

Data source: KEGG, BioCarta