Mouse qPCR Primer: Slc17a6|NM_001355150.1|MQP092149|solute carrier family 17 (sodium-dependent inorgan

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Validated All-in-One™ qPCR Primer for Slc17a6(NM_001355150.1) [Search again]

Catalog#: MQP092149(click here to view gene annotation page)
Symbol: Slc17a6
Species: Mouse
Target Gene Accession: NM_001355150.1
Alias: 2900073D12Rik, DNPI, VGLUT2
Gene Description: solute carrier family 17 (sodium-dependent inorgan
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Important Note: By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.

Gene References into function

VGLUT2 is found in vagal afferent endings in the esophagus, suggesting that glutamate is contained in, and probably released from, synaptic vesicles previously described in intraganglionic laminar endings
Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum.
Mossy terminals of unipolar brush cells are immunoreactive for VGLUT2; moreover, dendritic brushes are contacted by mossy terminals expressing VGLUT2 in organotypic cultures of mouse vestibulocerebellum.
developing hippocampal neurons transiently coexpressed VGLUT2 and VGLUT1 at distinct synaptic sites with different short-term plasticity
results indicate VGluT2-loaded glutamatergic axons mature earlier than VGluT1-laden axons in the telencephalic & diencephalic regions & suggest VGluT1 plays a transient developmental role in some glutamatergic systems that mainly use VGluT2 in adulthood
Mouse retinas were immunostained for vGluT1 and vGluT2. vGluT1 was localized to all cone pedicles and rod spherules, whereas vGluT2 was found in only 10% of the cone pedicles; which were distributed in a regular array, suggesting they are a distinct type
Vesicular VGLUT content is critically important for quantal size and VGLUT2-mediated reduction of excitatory drive affects specific forms of sensory processing.
We found differences in the time course of developmental expression, with VGLUT1 peaking around P14, while VGLUT2 increased gradually until adulthood.
about 12% of the total number of dorsal root ganglia neuron profiles expressed VGLUT1
Cajal-Retzius cells and subplate neurons are glutamatergic; these two cells express VGLUT1 and VGLUT2, respectively, as the transport system of glutamate in events orchestrated by these cells during cortical development.
These results suggest that thalamocortical axon terminals contained not only VGLUT2 but also VGLUT1, especially at P7-10.
VGluT2 is only found at terminals made by axons originating in the spinal cord and brainstem. By contrast, the two VGluT isoforms are co-localized in thalamocortical axon terminals targeting layer IV, but not in those targeting layer I.
Cloned the mouse VGLUT2 promoter and showed a novel molecular mechanism of glucose-induced mVGLUT2 transcription involving Sp1.
VGluT2 is the only vesicular glutamate transporter expressed in ventral tegmental area/substantia nigra dopamine neurons in vivo.