Human qPCR Primer: PMAIP1|NM_001382623.1|HQP119475|phorbol-12-myristate-13-acetate-induced protein 1

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Validated All-in-One™ qPCR Primer for PMAIP1(NM_001382623.1) [Search again]

Catalog#: HQP119475(click here to view gene annotation page)
Symbol: PMAIP1
Species: Human
Target Gene Accession: NM_001382623.1
Alias: APR, NOXA
Gene Description: phorbol-12-myristate-13-acetate-induced protein 1
Estimated Delivery: 1-3 weeks, but may vary. Please email sales@genecopoeia.com to confirm ETA.

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Important Note: By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.

Gene References into function

Noxa may not be of importance in the development of colorectal cancer
Noxa-induced mitochondrial dysfunction has a role in p53-mediated cell death
Noxa promoter responds directly to hypoxia via hypoxia-inducible factor (HIF)-1alpha.
BOK and NOXA are essential mediators of p53-dependent apoptosis
p53 activation is not necessary for up-regulation of NOXA in melanoma cells
E1A activation of p73 and the p53 apoptotic target Noxa can occur in the absence of a functional p53
component of the innate immune response of cells to viral infection, leading to enhanced cellular apoptosis
Noxa/Mcl-1 axis is an apoptosis rheostat in dividing cells, in a selective pathway that functions to restrain lymphocyte expansion and can be triggered by glucose deprivation
We conclude that Noxa and Bim establish a connection between FKHRL1 and mitochondria, and that both BH3-only proteins are critically involved in FKHRL1-induced apoptosis in neuroblastoma.
functional eIF2alpha played an essential role in PS-341-induced Noxa expression
suppression of Noxa in the lymph node environment contributes to the persistence of B-CLL at these sites and suggest that therapeutic targeting of Noxa might be beneficial
These data demonstrate the importance of Noxa induction in determining the apoptotic response to fenretinide and emphasise the role of Noxa in p53-independent apoptosis.
GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak.
Interferon gamma induces XAF1 and Noxa expression and potentiates apoptosis by STAT3 activation
PMAIP1 may play an important role in the progression of pancreatic cancer.
Noxa expression was enhanced by GSH depletion and inhibited by increasing GSH levels in the multiple myeloma cells
At higher concentrations of bortezomib, however, Noxa was also upregulated in resistant cells and this effect was sufficient to induce apoptosis.
the involvement of multiple pathways in Noxa-induced apoptosis that are triggered at mitochondria and the endoplasmic reticulum
Two splicing variants of the human Noxa geneare identified, which consists of three exons and two introns. Alternative splicing of exon 2 yields three transcripts. Transcript-1 joins exons 1 and 3 to encode Noxa of 54 amino acids.
hMTH1 plays an important role in protecting cells against H(2)O(2)-induced apoptosis via a Noxa- and caspase-3/7-mediated signaling pathway, thus conferring a survival advantage through the inhibition of oxidative-stress-induced DNA damage
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells