Introduction
E3 ubiquitin ligases are key components of the ubiquitin–proteasome system, selecting and tagging target proteins for degradation or regulation. With over 600 members, they control vital processes such as cell cycle, DNA repair, and immune signaling. Dysregulated E3 activity drives cancer, neurodegeneration, and inflammation, making E3s important targets for mechanistic studies and drug development.
Fig. Overview of the cascade process of ubiquitination.
GeneCopoeia offers a complete workflow for systematic E3 ligase studies—covering expression profiling, promoter/UTR regulation, CRISPR editing, ORF overexpression, and custom cell line generation—enabling researchers to quickly access all products and services needed for E3 functional analysis.
Fig. Systematic study of E3 ubiquitin ligases
