All human and mice ORF clones and related Lentivirus, AAV particles and recombinant proteins provided by GeneCopoeia are fully sequenced using Sanger sequencing by capillary electrophoresis and Amino Acid Sequences are guaranteed to be matched with NCBI database.

Cancer driver gene

Introduction

Cancer is a collection of diseases characterized by abnormal and uncontrolled cellular growth caused primarily by genetic mutations. Based on their role in cancer progression, driver genes can be classified into two main categories: oncogenes and tumor suppressor genes. Oncogene addiction refers to the phenomenon that certain tumours depend on one or more activated oncogenes, also known as driver oncogenes, to maintain their malignant biological phenotype.

For example, EGFR gene mutation is a common mutation in lung cancer, which makes the EGFR receptor persistently activated and the signalling process aberrant, leading to long-term uncontrolled cell proliferation and growth, and becoming one of the driver genes of lung cancer cells. Cancer cells require driver oncogenes for sustained function, whereas normal cells do not.

Therefore, targeting oncogenes as therapeutic targets allows targeted drugs to specifically kill tumour cells without damaging normal cells. Martínez-Jiménez et al. present the Integrative OncoGenomics (IntOGen) pipeline, which applies to somatic mutations of more than 28,000 tumours of 66 cancer types reveals 568 cancer genes and points towards their mechanisms of tumorigenesis. These cancer driver genes’ identification has led to the development of the paradigm of targeted anticancer therapies and, more generally, to the search for genomic biomarkers of prognosis and response to treatments.

Clone set information

Cat. no.	Species	Gene	Vector	Vector Type	Price
OC-GF022-M02	Human	620	pReceiver-M02	Expression-ready Non-viral	Inquire
OC-GF022-M35	Human	620	pReceiver-M35	Expression-ready Non-viral	Inquire
OC-GF022-M98	Human	620	pReceiver-M98	Expression-ready Non-viral	Inquire
OC-GF022-Lv105	Human	620	pReceiver-Lv105	Expression-ready Lentiviral	Inquire
OC-GF022-Lv242	Human	620	pReceiver-Lv242	Expression-ready Lentiviral	Inquire
OC-GF022-GC	Human	620	pDONR™ Vector	Gateway shuttle	Inquire

Clone list

For clone list please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.

Symbol	Accession	Species	Description	ORF length(bp)	Product ID
ABCC4	NM_001105515.3	Human	Homo sapiens ATP binding cassette subfamily C member 4 (ABCC4), transcript variant 2, mRNA.	2580	GC-T9124
ABCC4	NM_005845.5	Human	Homo sapiens ATP binding cassette subfamily C member 4 (ABCC4), transcript variant 1, mRNA.	3978	GC-T0262
ABL1	NM_005157.6	Human	Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1), transcript variant a, mRNA.	3393	GC-B0076
ABL1	NM_007313.3	Human	Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1), transcript variant b, mRNA.	3450	GC-T1921
ABL2	NM_005158.5	Human	Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant c, mRNA.	3504	GC-Z1255
ACKR3	NM_020311.3	Human	Homo sapiens atypical chemokine receptor 3 (ACKR3), mRNA.	1089	GC-H4618
ACSL3	NM_004457.5	Human	Homo sapiens acyl-CoA synthetase long chain family member 3 (ACSL3), transcript variant 1, mRNA.	2163	GC-I1896
ACSL6	NM_001009185.3	Human	Homo sapiens acyl-CoA synthetase long chain family member 6 (ACSL6), transcript variant 2, mRNA.	2169	GC-H1464
ACSM3	NM_005622.4	Human	Homo sapiens acyl-CoA synthetase medium chain family member 3 (ACSM3), transcript variant 1, mRNA; nuclear gene for mitochondrial product.	1761	GC-H1838
ACSM3	NM_202000.3	Human	Homo sapiens acyl-CoA synthetase medium chain family member 3 (ACSM3), transcript variant 2, mRNA; nuclear gene for mitochondrial product.	1317	GC-T2661
ACVR1	NM_001105.5	Human	Homo sapiens activin A receptor type 1 (ACVR1), transcript variant 1, mRNA.	1530	GC-T8297
ACVR1B	NM_004302.5	Human	Homo sapiens activin A receptor type 1B (ACVR1B), transcript variant 1, mRNA.	1518	GC-Y2812
ACVR1B	NM_020327.5	Human	Homo sapiens activin A receptor type 1B (ACVR1B), transcript variant 2, mRNA.	1362	GC-Y4814
ACVR1B	NM_020328.4	Human	Homo sapiens activin A receptor type 1B (ACVR1B), transcript variant 3, mRNA.	1641	GC-Z8332
ACVR2A	NM_001616.5	Human	Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 2, mRNA.	1542	GC-A0075
AFDN	NM_001207008.2	Human	Homo sapiens afadin, adherens junction formation factor (AFDN), transcript variant 1, mRNA.	5232	GC-A2202
AFDN	NM_001291964.2	Human	Homo sapiens afadin, adherens junction formation factor (AFDN), transcript variant 4, mRNA.	5346	GC-I3276
AJUBA	NM_032876.6	Human	Homo sapiens ajuba LIM protein (AJUBA), transcript variant 1, mRNA.	1617	GC-T1556
AJUBA	NM_198086.3	Human	Homo sapiens ajuba LIM protein (AJUBA), transcript variant 2, mRNA.	366	GC-H1000
AKT1	NM_001014431.2	Human	Homo sapiens AKT serine/threonine kinase 1 (AKT1), transcript variant 3, mRNA.	1443	GC-Z5980
AKT1	NM_005163.2	Human	Homo sapiens AKT serine/threonine kinase 1 (AKT1), transcript variant 1, mRNA.	1443	GC-A0022
AKT3	NM_001206729.2	Human	Homo sapiens AKT serine/threonine kinase 3 (AKT3), transcript variant 3, mRNA.	1398	GC-Z3429
AKT3	NM_005465.7	Human	Homo sapiens AKT serine/threonine kinase 3 (AKT3), transcript variant 1, mRNA.	1440	GC-R0021
ALDH2	NM_000690.4	Human	Homo sapiens aldehyde dehydrogenase 2 family member (ALDH2), transcript variant 1, mRNA; nuclear gene for mitochondrial product.	1554	GC-C0231
ALDH2	NM_001204889.2	Human	Homo sapiens aldehyde dehydrogenase 2 family member (ALDH2), transcript variant 2, mRNA; nuclear gene for mitochondrial product.	1413	GC-Z9566
ALK	NM_004304.5	Human	Homo sapiens ALK receptor tyrosine kinase (ALK), transcript variant 1, mRNA.	4863	GC-T1863
ALK	NM_001353765.2	Human	Homo sapiens ALK receptor tyrosine kinase (ALK), transcript variant 2, mRNA.	1659	GC-I5740
ALPK1	NM_025144.4	Human	Homo sapiens alpha kinase 1 (ALPK1), transcript variant 1, mRNA.	3735	GC-Z6155
AMER1	NM_152424.4	Human	Homo sapiens APC membrane recruitment protein 1 (AMER1), mRNA.	3408	GC-H2338
ANK1	NM_000037.4	Human	Homo sapiens ankyrin 1 (ANK1), transcript variant 3, mRNA.	5643	GC-Z5852
ANK1	NM_020476.3	Human	Homo sapiens ankyrin 1 (ANK1), transcript variant 1, mRNA.	5646	GC-Z7807
AR	NM_000044.6	Human	Homo sapiens androgen receptor (AR), transcript variant 1, mRNA.	2763	GC-E2325
AR	NM_001011645.3	Human	Homo sapiens androgen receptor (AR), transcript variant 2, mRNA.	1167	GC-E2336
AR	NM_001348061.1	Human	Homo sapiens androgen receptor (AR), transcript variant 3, mRNA.	1935	GC-I5618
ARAF	NM_001256196.2	Human	Homo sapiens A-Raf proto-oncogene, serine/threonine kinase (ARAF), transcript variant 2, mRNA.	1830	GC-Z0699
ARAF	NM_001654.5	Human	Homo sapiens A-Raf proto-oncogene, serine/threonine kinase (ARAF), transcript variant 1, mRNA.	1821	GC-B0257
ARHGAP35	NM_004491.5	Human	Homo sapiens Rho GTPase activating protein 35 (ARHGAP35), mRNA.	4500	GC-H1821
ARHGEF12	NM_015313.3	Human	Homo sapiens Rho guanine nucleotide exchange factor 12 (ARHGEF12), transcript variant 1, mRNA.	4635	GC-T0327
ARID2	NM_152641.4	Human	Homo sapiens AT-rich interaction domain 2 (ARID2), transcript variant 1, mRNA.	5508	GC-E2538
ARNT	NM_001197325.2	Human	Homo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT), transcript variant 4, mRNA.	2322	GC-Z8721
ARNT	NM_001668.4	Human	Homo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT), transcript variant 1, mRNA.	2370	GC-C0312
ARNT	NM_178427.3	Human	Homo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT), transcript variant 3, mRNA.	2325	GC-Z5281
ASXL1	NM_015338.6	Human	Homo sapiens ASXL transcriptional regulator 1 (ASXL1), transcript variant 1, mRNA.	4626	GC-E2820
ASXL2	NM_018263.6	Human	Homo sapiens ASXL transcriptional regulator 2 (ASXL2), transcript variant 1, mRNA.	4308	GC-H1988
ATG7	NM_001136031.3	Human	Homo sapiens autophagy related 7 (ATG7), transcript variant 2, mRNA.	2031	GC-T7632
ATG7	NM_001144912.2	Human	Homo sapiens autophagy related 7 (ATG7), transcript variant 3, mRNA.	1872	GC-H4078
ATG7	NM_006395.3	Human	Homo sapiens autophagy related 7 (ATG7), transcript variant 1, mRNA.	2112	GC-T0275
ATP1A1	NM_000701.8	Human	Homo sapiens ATPase Na+/K+ transporting subunit alpha 1 (ATP1A1), transcript variant 1, mRNA.	3072	GC-T0533
ATP1A1	NM_001160234.2	Human	Homo sapiens ATPase Na+/K+ transporting subunit alpha 1 (ATP1A1), transcript variant 4, mRNA.	2979	GC-H4345
AXIN1	NM_003502.4	Human	Homo sapiens axin 1 (AXIN1), transcript variant 1, mRNA.	2589	GC-E2160