Transforming growth factor beta-1, mature
| Catalog#: |
hRP-A1003M-CH |
| Symbol : |
TGFB1 |
| Protein Accession: |
NP_000651 |
| Description: |
Transforming growth factor beta-1, mature (contains two homodimeric 112 amino acid residue polypeptides linked by a disulfide bond) |
| Summary: |
Transforming growth factor beta-1 (TGF-beta-1) is a stable polypeptide growth factor with diverse biological functions. Generally, TGF-beta-1 stimulates cells of mesenchymal origin and inhibits cells of epithelial or neuroectodermal origin. In normal tissue, TGF-beta-1 is involved in wound healing, angiogenesis, hematopoiesis, mammary gland development, bone metabolism and skin formation. It is also involved in many pathological findings, such as inflammatory, fibrotic diseases and tumor development. TGF-beta-1 stimulates cells by binding with TGF receptors type I and type II. The binding allows the phosphorylation of the receptors and the signal is propagated through the phosphorylation of Smad protein. Shown below is the latent form of TGF-beta-1 that is secreted by most cells. Pro-TGF-beta-1 consists of non-covalently bound dimeric LAP and mature TGF-beta-1, and it is linked to LTBP by a disulfide bond through Cys 33. The mature recombinant human TGF-β1is cleaved from pro-TGFB1. It contains two homodimeric 112 amino acid residue polypeptides linked by a disulfide bond.
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| Source |
A DNA sequence encoding the human TGF beta 1 precursor protein was expressed in Chinese hamster ovary cells. Mature human TGF beta 1 was purified. |
| Application |
ELISA, Western Blot, Antibody Production, Arrays |
| Size |
5, 25, 100, 1000 ug |
| Purity |
> 98%, as determined by SDS-PAGE and visualized by silver stain. |
| Formulation and Storage |
50mM Glycine-HCl, 150mM NaCl, pH4.0.
Store at -80oC in small aliquots and avoid repeated freeze-thaw cycles. |
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| General protein Annotation Information |
| Entrez GeneID |
7040 |
| Nucleotide Acc |
NM_000660 |
| References |
- Derynck, R. and K. Miyazono (2008) “TGF-β and the TGF-β Family” in The TGF-β Family, Derynck, R. and K. Miyazono eds., Cold Spring Harbor Laboratory Press, p. 29.
- Redondo S, Santos-Gallego CG, and Tejerina T. TGF-beta1: a novel target for cardiovascular pharmacology. Cytokine Growth Factor Rev. 2007 Jun-Aug;18(3-4):279-86. Epub 2007 May 7.
- Teicher BA. Transforming growth factor-beta and the immune response to malignant disease. Clin Cancer Res. 2007 Nov 1;13(21):
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| OMIM |
219700 , 190180, 131300 |
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| Sequence Information |
| Peptide Length |
390 (precursor TGFB 1) |
| Nucleotide Length |
1173 |
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