| Catalog # |
hRP-U1430-EF011 |
| Size |
25 μg |
| Protein Name |
Human dual specificity phosphatase 12 |
| Protein Symbol |
DUSP12 |
| Original Source |
Homo sapiens |
| Expression System |
E.coli |
| GenBank Accession # |
NM_007240.1 |
| Uniprot Accession # |
Q9UNI6 |
| Description |
It is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. DUSP12 is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. |
| Application |
WB, ELISA, IP, antibody production, protein array |
| Fusion tag |
N-His |
| Peptide Length |
355aa(including fusion tag) |
| Molecular Weight |
39.5kDa(including fusion tag) |
| pI |
7.3 |
| Activity |
NA |
| Storage |
Storage buffer: 50mM Tris.Cl, 50mM NaCl, 2.5% Glycerol, pH8.0. Store at -80°C and avoid repeated freeze-thaw cycles. |
| Purity |
|
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