Recombinant Human PSMC3 Protein Data Sheet


Catalog # hRP-T3051-EF011
Size 25 μg
Protein Name Human 26S protease regulatory subunit 6A
Protein Symbol PSMC3
Original Source Homo sapiens
Expression System E.coli
GenBank Accession # BC008713.1
Uniprot Accession # P17980
Description The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, theimmuno proteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudo gene has been identified on chromosome 9.
Application WB, ELISA, IP, antibody production, protein array
Fusion tag N-His
Peptide Length 454aa(including fusion tag)
Molecular Weight 51.1kDa(including fusion tag)
pI 5.3
Activity NA
Storage Storage buffer: 20mM Tris.Cl, 100mM NaCl, 0.4M Urea, 50% Glycerol, pH8.0. Store at -80°C and avoid repeated freeze-thaw cycles.
Purity





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