Recombinant Human CAPN3 Protein Data Sheet

Catalog #	hRP-T2814-EF042
Size	100 μg
Protein Name	Human CAPN3 protein
Protein Symbol	CAPN3
Original Source	Homo sapiens
Expression System	E.coli
GenBank Accession #	BC003521.1
Uniprot Accession #	Q9BQC8
Description	Phosphatidylethanolamine-binding protein 1 binds ATP, opioids and phosphatidylethanolamine. It has lower affinity for phosphatidylinositol and phosphatidylcholine. It is thought that this protein also function as serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. PEBP-1 also inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. It seems to be mediated by a specific receptor.
Application	WB, ELISA, IP, antibody production, protein array
Fusion tag	none
Peptide Length	156aa
Molecular Weight	18.2kDa
pI	6.7
Activity	NA
Storage	Storage buffer: 20mM Tris.Cl, 50mM NaCl, 20% Glycerol, pH9.0. Store at -80°C and avoid repeated freeze-thaw cycles.
Purity

Reference:

• Calpain 3, the "gatekeeper" of proper sarcomere assembly, turnover and maintenance
• Calpains and human disease
• Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles
• Calpain 3 is a rapid-action, unidirectional proteolytic switch central to muscle remodeling
• Structure and physiological function of calpains
• Characterization of a new p94-like calpain form in human lymphocytes